The SynthArray Reactor System - Parallel Synthesis for Medicinal Chemists

The SynthArray reactors are a set of solution phase parallel synthesis reactors covering reaction volumes from 1 to 30 mL. Easily run parallel reactions from -78 to 250 C under inert atmosphere. They were designed to be usable by organic and medicinal chemists in the production of compounds for standard SAR analogue follow up as well as for library generation or reaction optimization in a process chemistry environment.

SynthArray reactors were designed to mimic the function of the classic "round bottom flask" while also enabling efficient parallel synthesis. By this we mean that it should be easy to use in a chemist’s hood, be compatible with standard laboratory equipment, and should allow a wide variety of reaction conditions by the addition of functionality. However, it should also be compatible with standard liquid handling robotics and the wide variety of devices designed for microtiter formats.

How does it work?

How much does it cost?

Features-

• Simple, Light Design - Array of glass reactor vessels in a microtiter format
• Multiple Scales - 8 to 60 mL reactors
• Inexpensive vessels - uses sealable disposable glass vials
• SynthArray-24 8 mL screw cap culture tubes
• SynthArray-6 20, 40 or 60 mL screw cap EPA vials
• Inert reaction conditions - simply add sleeve, top and gas line
• Reaction vessels held at their top, like a round bottom flask
• Versatile options for heating and cooling
• Reaction mixtures easy to see
• Quick removal from heat, just pick it up
• Reflux - add on condenser when needed
• Standard SBS microtiter array formats, compatible with
• Filter plates
• Filtration devices
• Liquid handling robots
• Solid addition plates
• Software for handling arrays
• Compact design - easily fits in a drawer when not in use
• Easy to clean - toss the glass, rinse with acetone and send it to the dishwasher
• Hood compatible
• Fits nicely on IKA or other stirring hotplate
• Heater block/alignment guide fits IKA thermo-couple
• Inexpensive to own and use
• Superior Design lowers complexity and cost relative to the competition
• Disposable glass reactors make it inexpensive to use
• Available parts (like the tube holder) can be used separately

A report describing the SynthArray reactors was recently published in The Journal of Combinatorial Chemistry.

Novel Array Reactors for Parallel Synthesis. Philip F. Hughes, Thomas H. Graham and Jose S. Mendoza. J. Comb. Chem.; 2004, 6, 308-311.